动物双歧杆菌乳亚种Bi-07

科学研究

动物双歧杆菌乳亚种Bi-07已经单独进行消化健康功效研究，并且经常与NCFM®、Bl-04和 Lpc-37组合进行消化健康功效研究。^1–2该菌株已经在超过91篇科学出版物中发表，并经过覆盖从婴儿（7月龄）到老年人群（70岁）的33项临床试验。Bi-07拥有悠久的安全使用历史，具有良好的肠道存活适应性，并且对肠道细胞系有很强的粘附性。^3-9

参考文献:
1. Ouwehand AC, DongLian C, Weijian X, et al. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014;32:458-463. 2. Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009;124(2):e172-179. 3. Candela M, Bergmann S, Vici M, et al. Binding of human plasminogen to Bifidobacterium. J Bacteriol. 2007;189:5929-5936. 4. Candela M, Biagi E, Centanni M, et al. Bifidobacterial enolase, a cell surface receptor for human plasminogen involved in the interaction with the host. Microbiology. 2009;155:3294-3303. 5. Candela M, Miccoli G, Bergmann S, et al. Plasminogen dependent proteolytic activity in Bifidobacterium lactis. Microbiology. 2008;154:2457-2462. 6. Candela M, Perna F, Carnevali P, et al. Interaction of probiotic Lactobacillus and Bifidobacterium strains with human intestinal epithelial cells: adhesion properties, competition against enteropathogens and modulation of IL-8 production. Int J Food Microbiol. 2008;125:286-292. 7. Candela M, Fiori J, Dipalo S, et al. Rapid MALDI-TOF-MS analysis in the study of interaction between whole bacterial cells and human target molecules: Binding of Bifidobacterium to human plasminogen. J Microbiol Methods. 2008;73:276–278. 8. Candela M, Seibold G, Vitali B, et al. Real-time PCR quantification of bacterial adhesion to Caco-2 cells: Competition between bifidobacterial and enteropathogens. Res Microbiol. 2005;156:887–895. 9. Candela M, Turroni S, Centanni M, et al. Relevance of Bifidobacterium animalis subsp. lactis plasminogen binding activity in the human gastrointestinal microenvironment. Appl Environ Microbiol. 2011;77:7072-7076.