乳双歧杆菌HN019

科学研究

乳双歧杆菌HN019在乳制品中使用已有数十年历史，其益生菌特性已经在超过111项科学出版物中经过详细研究。该菌株已经被证明对酸性环境具有耐受性，且在经过人体肠道后仍然能够存活。^1-3机理数据显示乳双歧杆菌HN019可能会影响结肠运动——多项对乳双歧杆菌HN019单独进行的或与益生元或其他益生菌株组合进行的临床试验结果显示，它能提高排便频率较低人群的肠道运转功能。^4-6 乳双歧杆菌HN019还被证明能够调节免疫功能，特别是增强老年人的细胞免疫活性。⁷

参考文献:
1. Gopal PK, Prasad J, Gill HS Effects of the consumption of Bifidobacterium lactis HN019 (DR10 TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutrition Research. 2003;23:1313-1328. 2. Prasad J, Sazawal S, Dhingra U, Gopal PK Detection of viable Bifidobacterium lactis HN019 (DR10TM) in stools of children during a synbiotic dietary intervention trial. Intl Dairy J. 2013;30:64-67. 3. Wickens K, Black PN, Stanley TV, et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clinical Immunology. 2008;122:788-794. 4. Dalziel JE, Anderson RC, Peters JS, et al. Promotility action of the probiotic Bifidobacterium lactis HN019™ extract compared with prucalopride in isolated rat large intestine. Frontiers in Neuroscience. 2017; 11. 5. Ibarra A, Latreille-Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28-day Bifidobacterium animalis subsp. lactis HN019™ supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled and dose-ranging trial. Gut Microbes. 2017; Dec 11:0. 6. Waller PA, Gopal PK, Leyer GJ, et al. Dose-response effect of Bifidobacterium lactis HN019™ on whole gut transit time and functional gastrointestinal symptoms in adults. Scandinavian J Gastroenterology. 2011;46:1057-1064. 7. Miller LE, Lehtoranta L, Lehtinen MJ. The Effect of Bifidobacterium animalis ssp. lactis HN019™ on cellular immune function in healthy elderly subjects: systematic review and meta-analysis. Nutrients. 2017;9:191.